Parameters of systemic hemodynamics in conscious rats with acute streptozotocin diabetes
Kuznetsova, L.V.; Medvedeva, N.A.; Medvedev, O.S.
Biulleten' Eksperimental'noi Biologii i Meditsiny 113(3): 250-252
1992
ISSN/ISBN: 0365-9615 PMID: 1421217 Document Number: 395074
The effect of acute streptozotocin-induced diabetes mellitus on the systemic hemodynamic parameters was studied in conscious rats by thermodilution technique. Male Wistar rats were made diabetic with a single intravenous injection of streptozotocin (STZ, 50 mg/kg). The most important finding of this work was the elucidation of the systemic vasodilation and increased cardiac index one day after STZ injection. Such alteration in hemodynamic parameters could result in the increased blood flow and capillary hypertension in some vascular beds and, therefore, be considered as a pathogenic factor in the development of diabetic microangiopathy.