Kinetics of plasma triglycerides in rats with streptozotocin diabetes
Bobek, P.; Chorváthová, V.; Ozdín, L.
Physiologia Bohemoslovaca 30(1): 35-40
1981
ISSN/ISBN: 0369-9463 PMID: 6452636 Document Number: 168931
Streptozotocin diabetes [45 mg/kg] in rats fed on a standard diet, with insulin substitutional therapy - 66 [nkat/kg]/d [[4 U/kg b.w.]d] for the first 3 days - led during an 8 days' experiment to marked hypertriglyceridaemia [4.86 mmol/l] and to triglyceride accumulation in the liver [22.35 mmol/kg]. The endogenous triglyceride secretion rate, studied by means of a Triton WR 1339 block of lipoprotein lipase, was almost 30 % lower in diabetic rats. The half-time of plasma 14C-triglycerides [labelled endogenously with 14C-1-palmitic acid] almost doubled and the fractional turnover rate fell to half the value in the control animals. Hypertriglyceridaemia in diabetic rats [60 % insulin deficiency] is caused by slower removal of lipoprotein triglycerides from the plasma space, owing to reduced lipolytic activity in the peripheral tissues.