Estimating cancer latency using data from a case-control study with time-related factors. I. a general multivariate theory and algorithm
Liu, Y.Y.
Zhonghua Zhong Liu Za Zhi 14(1): 37-41
1992
ISSN/ISBN: 0253-3766 PMID: 1396045 Document Number: 394869
In the present paper, a general multivariate approach, estimating cancer latency using data from a case-control study with time-related factors, is proposed based on the theory for risk analysis of states. Making use of a forward-analysis and backward-synthesis strategy and excess exposure fraction, this approach can simultaneously accomplish multivariate logistic regression analysis and estimation of susceptible exposure ages and latency distribution. The latency is resolved into a accumulative period and preneoplastic period. It gives a theoretical interpretation for primary and secondary prevention of cancer.