Medical treatment of Cushing's syndrome with aminoglutethimide and ketoconazole
Kong, H.L.; Lee, K.O.; Cheah, J.S.
Singapore Medical Journal 33(5): 523-524
1992
ISSN/ISBN: 0037-5675 PMID: 1455284 Document Number: 394705
We report a 54-year-old Chinese man with Cushing's syndrome from bilateral adrenal adenomata in whom surgery was contraindicated because of his intercurrent medical conditions. Instead, he was successfully treated with aminoglutethimide 0.75 gm/day (which reduced his 24-hour urinary free cortisol from 628 nmol/day to 177 nmol/day in 4 weeks), followed by ketoconazole 0.6 gm/day which continued to suppress the urinary free cortisol level. We conclude that aminoglutethimide or ketoconazole offers a viable non-surgical alternative to the treatment of Cushing's syndrome.