Effect of dexfenfluramine on energy expenditure in man
Schutz, Y.; Munger, R.; Dériaz, O.; Jéquier, E.
International Journal of Obesity and Related Metabolic Disorders Journal of the International Association for the Study of Obesity 16(Suppl 3): S61-S66
1992
ISSN/ISBN: 0307-0565 PMID: 1338324 Document Number: 394167
A short review has been made of the experimental studies performed in man, in which the effect of dexfenfluramine (D-F) on resting energy expenditure has been explored. It appears that the extent to which D-F possesses thermogenic properties (in addition to its anorectic effect) still remains controversial. Some investigators found either no significant increase in energy expenditure in response to the drug or a moderate effect in post-absorptive and/or postprandial state. It may be reasonable to assume that the supplementary weight loss observed with D-F as compared to a placebo can be primarily attributed to its anorectic effect rather than to its putative thermogenic effect.