Mechanisms of the protective action of neoton in immune heart diseases
Moĭbenko, A.A.; Marchenko, G.I.; Popovich, L.F.; Cherednichenko, G.A.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 2: 30-33
1992
ISSN/ISBN: 0031-2991 PMID: 1408389 Document Number: 393877
An attempt was made to reveal some membrane mechanisms of the protective effect of phosphocreatine (Neoton produced by the Schiappare firm, injected intravenously in a dose of 500 mg/kg) predominantly on the endothelium of the coronary vessels and the cardiomyocytes. Local immune damage to the left-ventricular myocardium was produced by intracoronary injection of anticardiac antibodies. Morphological and biochemical studies showed damage to the membrane of endotheliocytes and cardiomyocytes: reduced activity of Na-Cametabolism and Na-, K-ATPase. The obtained data bore evidence of the protective effect of phosphocreatine in immune damage to the heart, which was realized on the level of the endotheliocyte and cardiomyocyte membranes.