Rhabdomyolysis due to simvastin. Apropos of a case with review of the literature

Dromer, C.; Vedrenne, C.; Billey, T.; Pages, M.; Fournié, B.; Fournié, A.

Revue du Rhumatisme et des Maladies Osteo-Articulaires 59(4): 281-283

1992


ISSN/ISBN: 0035-2659
PMID: 1496277
Document Number: 392469
A new case of simvastatin-induced acute rhabdomyolysis with heart failure after initiation of treatment with fusidic acid is reported. In most reported instances, statin treatment was initially well tolerated with muscle toxicity developing only after addition of another drug. The mechanism of this muscle toxicity is unelucidated but involvement of a decrease in tissue Co enzyme Q is strongly suspected.

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