Prevention of mouse liver metastases by perioperative immunostimulation using OK-432
Ban, S.
Nihon Geka Hokan. Archiv für Japanische Chirurgie 61(1): 67-73
1992
ISSN/ISBN: 0003-9152 PMID: 1530383 Document Number: 392309
Two surgical procedures were required to make experimental model of liver metastasis (SC42-DS). In this paper, the protective effects of OK432 against liver metastasis were examined experimentally, as a immunotherapeutic agent under perioperative condition. In 5 combinations of administration, OK432 showed some different effects on liver metastasis, however, in general, simultaneous intrasplenic injection of OK432 reduced liver metastasis. From this result, the efficacy of intraoperative OK432 via portal vein was speculated.
Document emailed within 1 workday
Related Documents
Ban, S. 1992: Experimental model of liver metastases of the mouse Nihon Geka Hokan. Archiv für Japanische Chirurgie 61(1): 62-66Kiricuta, I.; Todorutiu, C.; Risca, R. 1978: Prophylaxis of metastases formation by prolonged non-specific immunostimulation associated with heparin therapy Physiological Chemistry and Physics 10(3): 247-253
Yoon, S.S.; Eto, H.; Lin, C.M.; Nakamura, H.; Pawlik, T.M.; Song, S.U.; Tanabe, K.K. 1999: Mouse endostatin inhibits the formation of lung and liver metastases Cancer Research 59(24): 6251-6256
Satake, M.; Yoshimatsu, K.; Ito, Y.; Imaizumi, R.; Matsumura, M.; Katagiri, S.; Takiguchi, S.; Matsumoto, T.; Kinoshita, J.; Koike, T.; Naritaka, Y. 2016: A Case of Hepatectomy for Liver Metastases during Long-Term Chemotherapy after Three Hepatectomies for Liver Metastases from Rectal Cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 43(12): 1721-1723
Taylor, I. 1981: Studies on the treatment and prevention of colorectal liver metastases Annals of the Royal College of Surgeons of England 63(4): 270-276
Takano, S.; Moriguchi, M.; Seki, N.; Higaki, T.; Watanabe, Y.; Takahashi, T.; Ito, Y.; Oishi, H.; Nakata, Y.; Kono, S. 1994: The significance of portal infusion chemotherapy for prevention of recurrence in residual liver after hepatectomy for metastases from colorectal cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 21(13): 2176-2178
Herzovi, F. 1978: Recurrent respiratory diseases in young children and the value of nonspecific immunostimulation in the prevention and treatment of such diseases Revista de Pediatrie Obstetrica Si Ginecologie. Pediatria 27(3): 245-248
Kojima, S. 1989: Perioperative adjuvant chemotherapy in the treatment of lymph node metastases of colorectal cancer Nihon Geka Gakkai Zasshi 90(5): 686-694
Yigit, R.; Fisher, J.W. 1983: Activation of erythroid colony forming cells (CFU-E) by cyclic AMP in adult mouse bone marrow and fetal mouse liver cultures Haematologica 68(3): 301-311
Heisterkamp, J.; van Bommel, J.; Hop, W.C.; Tilanus, H.W.; Zondervan, P.E.; IJzermans, J.N. 1999: P53 overexpression in colorectal metastases confined to the liver and outcome of liver resection Hepato-Gastroenterology 46(30): 3109-3114
Navarro-Freire, F.; Navarro-Sánchez, P.; Mirón-Pozo, B.; Delgado-Ureña, Mía.Teresa.; Jiménez-Ríos, Jé.Antonio.; García-López, P.Antonio.; Arcelus-Martínez, J.Ignacio. 2015: Recurrence of liver metastases from colorectal cancer and repeat liver resection Revista Espanola de Enfermedades Digestivas: Organo Oficial de la Sociedad Espanola de Patologia Digestiva 107(12): 732-739
Higuchi, T.; Ishikawa, T.; Tsukamoto, S.; Fujimori, Y.; Oda, G.; Okazaki, S.; Ishiguro, M.; Kobayashi, H.; Iida, S.; Uetake, H.; Yasuno, M.; Enomoto, M.; Sugihara, K. 2009: A case of advanced rectal cancer with severe liver dysfunction due to multiple liver metastases Gan to Kagaku Ryoho. Cancer and ChemoTherapy 36(12): 2181-2183
Asai, K.; Murata, M.; Saso, K.; Yamada, M.; Sawami, H.; Suzuki, R.; Fukunaga, H.; Tanaka, N.; Yamamoto, M.; Hiratsuka, M. 2016: A Case of Metachronous Liver Metastases of Gall Bladder Cancer Successfully Treated by Liver Resection Gan to Kagaku Ryoho. Cancer and ChemoTherapy 43(12): 2092-2094
Takata, N.; Harada, K.; Yoshinaka, I.; Maeda, M.; Nasu, J.; Ikeda, R. 2000: Multimodality therapy for synchronous liver metastases of gastric cancer--significance of aggressive hepatic resection of liver lesions Gan to Kagaku Ryoho. Cancer and ChemoTherapy 27(12): 1916-1919
Urata, K.; Kawasaki, S. 2001: Liver transplantation for liver metastases of colorectal cancer Nihon Geka Gakkai Zasshi 102(5): 409-411
Philip, S.; Bakula, G.; Jacobs, M.; Mittal, V.K. 2017: The Management of Patients with Colorectal Cancer and Synchronous Liver Metastases or Indeterminate Liver Lesions: a Community Teaching Hospital Experience American Surgeon 83(1): E33-E35
Durczyński, A.; Szymański, D.; Nowicki, Mł.; Hogendorf, P.; Stefańczyk, L.; Strzelczyk, J. 2011: Two-stage liver resections with portal branch ligation--a novel treatment strategy for patients with initially irresectable, bilobar colorectal liver metastases Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego 30(178): 268-271
Kitamura, Y.; Katayose, Y.; Miura, K.; Yamamoto, K.; Yoshida, H.; Ottomo, S.; Motoi, F.; Rikiyama, T.; Egawa, S.; Sasaki, I.; Unno, M. 2010: Long-term survival case after liver resection and postoperative hepatic arterial infusion for multiple liver metastases from rectal cancer Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(12): 2641-2643
Mori, T.; Munakata, M.; Kasai, M.; Nozaki, T.; Kawamura, S.; Sawamura, N.; Hiraga, H.; Sakata, Y. 2004: Successful treatment of 5-FU intraarterial infusion on the third postoperative day for a patient with multiple liver metastases from colon cancer and high risk of liver failure Gan to Kagaku Ryoho. Cancer and ChemoTherapy 31(7): 1101-1103
Meyhoff, C.S. 2016: Active prevention of perioperative hypothermia Ugeskrift for Laeger 178(32)