Adherence to dietetic treatment, the nutritional metabolic status and the progression of chronic kidney failure
Garini, G.; Arisi, L.; Borrini, A.; Fiaccadori, E.; Guariglia, A.; Magnati, G.; Mazzi, A.; Ronda, N.; Savazzi, G.; Borghetti, A.
Annali Italiani di Medicina Interna Organo Ufficiale Della Societa Italiana di Medicina Interna 7(2): 71-77
1992
ISSN/ISBN: 0393-9340 PMID: 1467127 Document Number: 392173
Effects of two protein restricted diets on dietary compliance, nutritional and metabolic state, and progression of chronic renal failure (CRF) were investigated. Twenty-one patients with CRF were randomly assigned to either a conventional low protein diet (0.6 g of protein/kg b.w./day) or to a very low protein diet, providing 0.4 g of protein/kg b.w./day, supplemented with a mixture of essential amino acids which contained HIS, TYR and a high proportion of branched chain amino acids. Nutrition, assessed by body weight, anthropometry, serum protein levels and nitrogen balance studies, was maintained in all patients. Some metabolic abnormalities of CRF (i.e., secondary hyperparathyroidism, glucose intolerance) improved in both groups. The supplemented diet provided better adherence to protein prescription, corrected the depletion of VAL and LEU in muscle and was more effective than conventional diet in slowing the rate of progression of CFR.