Comparative studies of fibrogenic properties of wollastonite, chrysotile and crocidolite
Woźniak, H.; Wiecek, E.; Tossavainen, A.; Lao, I.; Kołakowski, J.
Medycyna Pracy 37(5): 288-296
1986
ISSN/ISBN: 0465-5893 PMID: 3027496 Document Number: 3916
Fibrogenous effects of wollastonite, chrysotile and crocidolite have been investigated in experiments on animals. (Wollastonite is a calcium silicate of fibrous structure, occasionally applied as asbestos substitute). The experimental animals were intratracheally administered single doses of 50 mg of the test material suspended in 0.6 ml of physiological NaCl solution. The animals were decapitated 3, 6 and 9 months after the experiment. Fibrogenic properties were evaluated basing on the weight of wet lungs, content of lipids and hydroxyproline in lungs, as well as histopathological tests of lungs, mediastinal lymph nodes and spleen. Histopathological preparations were evaluated using an optical, microscope or transmission electron microscope. The findings of biochemical, pathomorphological, and ultrastructural studies demonstrated slight fibrogenic effects of wollastonite, as compared to chrysotile and crocidolite.
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