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The metabolic interaction of cobalt and silver in the body during their combined action

Kazimov, M.A.

Gigiena Truda i Professional'nye Zabolevaniya (11-12): 23-27

1992

ISSN/ISBN: 0016-9919
PMID: 1303391
Document Number: 391330
Mixtures of cobalt and silver in ratio (0.2:0.4), (0.2:0.2) and (0.2:0.1) mg/kg were once administrated intraperitoneally and intratracheally to white rats. Metabolism of the metals was studied. Combined exposure to metals appeared to influence greatly on their toxicokinetics. The co-action between metals appears during their absorption into the blood--the elevated peritoneal absorption of cobalt depresses that of silver. The reverse relationship is demonstrated during the intratracheal insertion. Such peculiarities of co-action exist during the further stages of metabolism.

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