Changes in the phagocytic activity of macrophages under the action of different doses of antibiotics
Aprikian, V.S.; Mikhaĭlova, A.A.; Petrov, R.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1992(9-10): 71-74
1992
ISSN/ISBN: 0372-9311 PMID: 1481611 Document Number: 391258
Penicillin, streptomycin and gentamicin, when introduced into mice in a single injection in doses of 0.5-500,000 U/kg, produced different changes in the phagocytic activity of mouse peritoneal macrophages. Bactericidal doses of these antibiotics either suppressed the activity of macrophages or left it unchanged. Their sub-bactericidal doses enhanced the phagocytic activity of macrophages. Combined use of penicillin and streptomycin produced a synergic effect.