Effect of sodium butyrate on glucocorticoid-sensitive and -resistant P1798 lymphosarcoma
Chang, Y.F.; Wu, L.H.; Liu, T.Y.; Yang, J.C.; Chi, C.W.
Zhonghua Yi Xue Za Zhi 49(1): 1-5
1992
ISSN/ISBN: 0578-1337 PMID: 1312378 Document Number: 390526
This study aims to examine the effect of sodium butyrate on the viability and the level of glucocorticoid receptors and cells cycle progression in glucocorticoid-sensitive and -resistant P1798 cells. Our results indicated that low levels of sodium butyrate had no effect on either the viability or the receptor level. However, high-level (5 mM) sodium butyrate appeared to reduce cell viability as well as the glucocorticoid receptor level. On the other hand, sodium butyrate inhibited cell cycle progression in a dose-dependent manner. This response was similar in both the glucocorticoid-sensitive and -resistant P1798 cells. Results from this study suggested that the sodium butyrate induced effect may be cell cycle related.