Alkylation reaction of phosphorus oxyacids
Ayukawa, H.; Ohuchi, S.; Higashiya, S.; Singh, R.K.; Ishikawa, M.; Hata, T.
Nucleic Acids Symposium Series 27: 91-92
1992
ISSN/ISBN: 0261-3166 PMID: 1289839 Document Number: 389817
Alkylation reactions of phosphorus oxyacids (i.e. phosphoric acid, phosphorous acid, hypophosphorous acid) were examined by means of several methods for the synthesis of the corresponding esters. These reactions were applied to the synthesis of oligonucleotide having phosphotriester bond or phosphonate diester bond.
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