Synthesis of a new organic pyrophosphate in large quantities is induced in some bacteria by oxidative stress
Ostrovsky, D.; Kharatian, E.; Malarova, I.; Shipanova, I.; Sibeldina, L.; Shashkov, A.; Tantsirev, G.
Biofactors 3(4): 261-264
1992
ISSN/ISBN: 0951-6433 PMID: 1605835 Document Number: 388352
Brevibacterium ammoniagenes and Micrococcus luteus were shown to synthesize up to 50 mM of a novel substance, 2-methylbutan-1,2,3,4-tetraol 2,4-cyclopyrophosphate, in response to oxidative stress created by benzyl viologen and other redox mediators under aerobic conditions. The substance, which represents greater than 50% of the extractable phosphorus, is suggested to play a role as a bacterial antistressor and is thought to be a product of condensation of two molecules of phosphoenolpyruvate whose accumulation is prompted by conversion of intracellular NADPH into an oxidized form.