Ethanol-induced oxidative stress in the rat cerebellum
Rouach, H.; Park, M.K.; Orfanelli, M.T.; Janvier, B.; Nordmann, R.
Alcohol and Alcoholism . Suppl 1: 207-211
1987
ISSN/ISBN: 1358-6173 PMID: 3426681 Document Number: 300555
An acute ethanol load (50 mmol/kg, i.p.) produces an increase in lipid peroxidation in the rat cerebellum. The levels of ascorbate and alpha-tocopherol, which represent efficient antioxidants acting synergetically, are decreased. This decrease seems highly indicative of a consumption of the antioxidants in quenching free radicals and suggests that acute ethanol induces an oxidative stress at the cerebellar level. As allopurinol, a xanthine oxidase inhibitor, prevents the decrease in alpha-tocopherol, xanthine oxidase may contribute to this oxidative stress.