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Genetic and immunological studies on polypeptides encoded by the vir locus of Bordetella pertussis

Stibitz, S.; Yang, M.S.

Developments in Biological Standardization 73: 87-91

1991

ISSN/ISBN: 0301-5149
PMID: 1778338
Document Number: 387681
We report here the results of genetic and immunological studies of the vir locus of Bordetella pertussis. These studies have allowed the determination of the cellular compartment that each of the vir-encoded polypeptides occupies, and have allowed the detection of each of them in crude extracts of Bordetella pertussis cells. From these studies it can be seen that the vir locus encodes two polypeptides, one a transmembrane sensing and signalling protein and the second a cytoplasmic regulatory protein. These proteins belong to the family of bacterial regulatory proteins known as two-component systems. A simple model for signal transduction in this organism is put forward.

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