Normalizing effects of antidepressive imipramine on reorganization of circadian motility in light period shift in pinealectomized rats
Arushanian, E.B.; Baturin, V.A.; Arushanian, A.E.
Biulleten' Eksperimental'noi Biologii i Meditsiny 112(12): 595-597
1991
ISSN/ISBN: 0365-9615 PMID: 1777619 Document Number: 386932
A change in the reorganization of the circadian motor activity following a 10-hour shift in the photo period was observed in the pinealectomized rats. After antidepressant imipramine (10 mg/kg, 14 days), such reorganization of the circadian rhythm was also changed in the intact animals. At the same time imipramine eliminated the disruption in the resynchronization of the daily motility following pinealectomy.