Effect of selenium on the connective tissue metabolism in rats
Kucharz, E.I.; Olczyk, K.; Sonecki, P.
Gigiena Truda i Professional'nye Zabolevaniya (12): 4-5
1991
ISSN/ISBN: 0016-9919 PMID: 1667866 Document Number: 386589
Rats were chronically exposed to poisonous sodium selenite in concentrations 0.5 mg/kg b. m. for 10 weeks. As a result, hydroxyproline contents in blood serum increased, as well as its excretion with urine. It was proved that the procedure enhanced urinary glycosaminoglycane excretion and increased the contents of the protein-related glycosaminoglycanes in the serum. This was accompanied by increased quantities of keratane sulphate and heparin sulphate. The results confirmed that selenium poisonings influenced connective tissues.