The role of vitamin K in the metabolism of connective tissue biopolymers (review)
Sharaev, P.N.
Voprosy Meditsinskoi Khimii 30(1): 13-17
1984
ISSN/ISBN: 0042-8809 PMID: 6369774 Document Number: 226055
Metabolism of connective tissue biopolymers was studied under conditions of various content of vitamin K in the body. The data obtained suggest the existence of a new metabolic effect of vitamin K--its participation as an allosteric activator in regulation of glucosamine synthetase (EC 5.3.1.19). The anabolic effect of vitamin K on connective tissue is apparently related to an increase in the rate of biosynthesis of glucosamine-6-phosphate--general precursor of glycosaminoglycans, glycoproteins and hexosamine-containing glycolipids.