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Vitamin E and its structural analogs in tuberculosis

Panasiuk, A.V.; Penenko, O.R.; Kuz'menko, I.V.; Suslov, E.I.; Klimenko, M.T.; Kuznitsa, N.I.; Tumanova, T.A.; Makovetskiĭ, V.P.; Donchenko, G.V.

Ukrainskii Biokhimicheskii Zhurnal 63(5): 83-88

1991

ISSN/ISBN: 0201-8470
PMID: 1788879
Document Number: 385729
Efficiency of tocopherol, its analog with a shortened side chain as well as their quinons for tuberculosis was determined. All the studied compounds inhibited peroxide-formation processes in the liver homogenate and mitochondria. The vitamin E amount in the blood is considerably decreased in case of tuberculosis. The studied analogs increased its content and possessed a weak tuberculostatic but expressed antiedemic and antiinflammatory action. Administration of vitamin E in combination with isoniazid to sick animals had a favourable effect on the processes of tissue respiration and oxidative phosphorylation. If taking a sum of characters, tocopherol acetate with a shortened side chain is the most efficient of all the analogs under study for the tuberculosis therapy.

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