Additive effects of carboplatin (CBDCA) and Co-60 gamma rays in human tumor cells in vitro
Flentje, M.; Latz, D.; Haner, U.; Hör, A.; Trinh, S.; Wannenmacher, M.
Strahlentherapie und Onkologie Organ der Deutschen Rontgengesellschaft . 167(4): 244-249
1991
ISSN/ISBN: 0179-7158 PMID: 2028403 Document Number: 385422
In vitro investigations on the combination effect of radiation and carboplatin (CBDCA) in three human cell lines (HeLa, MRI-186 Caski) show purely additive effects. Study of the molecular lesions gave considerable differences in the time course of repair of radiation induced DNA-double strand-breaks and of formation of DNA-crosslinks by carboplatin. However, sequential treatment with intervals of up to +/- 24 hours resulted also in an additive effect. In the experimental systems studied, a true radiosensitization was not demonstrated.
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