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Prevention of post-resuscitation metabolic disorders by the antioxidant oxypyridine-6

Dolgikh, V.T.

Voprosy Meditsinskoi Khimii 37(5): 12-16

1991

ISSN/ISBN: 0042-8809
PMID: 1759387
Document Number: 384910
Acute mortal hemorrhage in rats induced excessive activation of lipid peroxidation, while accumulated high amounts of lipid hydroperoxides impaired energy metabolism in brain and heart tissues. Preadministered antioxidant hydroxypyridine-6, which increased the lipids antioxidation activity and reduced inhibition of the antioxidative enzymes, limited distinctly the lipid peroxidation rate in brain, heart, lung and liver tissues and contributed to maintaining energy metabolism. The drug diminished 2-fold the early postresuscitation lethality.

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