Genetic load of hereditary diseases in populations of the Krasnodar Krai
Petrin, A.N.; Golubtsov, V.I.; Galkina, V.A.; Ginter, E.K.; Revazov, A.A.; Khisamova, M.V.; Mikhaĭlova, L.K.; Khlevnikova, O.V.; Sukolin, G.I.; Poleshchuk, V.V.
Genetika 27(2): 345-352
1991
ISSN/ISBN: 0016-6758 PMID: 1831430 Document Number: 384604
Medico-genetical study of populations living in Krasnodar district was carried out. The mean value of genetic load contributed by autosomal dominant diseases composed 0.92 +/- 0.06, this value being 0.56 +/- 0.04 for autosomal recessive and 0.36 +/- 0.05 for X-linked recessive disorders per one thousand. Comparative analysis of genetical load in urban and rural populations demonstrated that they had no differences in relation to genetical load contributed by autosomal recessive and X-linked recessive disorders. At the same time, significant differences were noted between the populations concerning genetic load contributed by autosomal-dominant disorders.