Three-generation Reproduction studies with FWAs
Keplinger, M.L.; Lyman, F.L.; Calandra, J.C.
Environmental Quality and Safety. Suppl 4: 230-238
1975
ISSN/ISBN: 0340-4714 PMID: 1064543 Document Number: 384122
Four fluorescent whitening agents (FWAs), compounds (1), (2), (3) and (4) (see table 1) were investigated for their effects on the reproductive performance of albino rats through 3 successive 2-litter generations at dietary levels of 40, 200, and 1000 ppm. Except for slight and random effects of compound (4) on pup survival, no adverse effects were observed. The random effects with compound (4) were not consistently related to either dose level or cumulative duration of exposure through the 3 generations.