Transmembrane and intracellular signal transduction during palatal ontogeny
Greene, R.M.; Linask, K.K.; Pisano, M.M.; Weston, W.M.; Lloyd, M.R.
Journal of Craniofacial Genetics and Developmental Biology 11(4): 262-276
1991
ISSN/ISBN: 0270-4145 PMID: 1667402 Document Number: 383788
Investigations of the pathogenesis of cleft palate have been hampered by the complexity of normal craniofacial ontogenesis and by an incomplete understanding of mechanisms involved in normal palate development. This article deals with cellular aspects of the developing craniofacial region and discusses the facts and problems in the field as they relate to the normal development of the secondary palate, with emphasis on the regulation of hormone- and growth factor-induced transmembrane signalling and intracellular signal transduction.