PPARs-mediated intracellular signal transduction
Fujii, H.
Nihon Rinsho. Japanese Journal of Clinical Medicine 63(4): 565-571
2005
ISSN/ISBN: 0047-1852 PMID: 15828221 Document Number: 588612
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPARs consist of three isotypes named PPARalpha (NR1C1), PPARbeta/delta (NR1C2) and PPARgamma (NR1C3) in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. Although each isotype fulfills distinct functions, PPARs function not only as an important fatty acid sensor that regulate lipid, carbohydrate and amino acid metabolism but also play an important role in various signaling pathways (immunity, inflammation, apoptosis and cell differentiation). In this review, I focus on emerging knowledge about PPARs roles in various intracellular signaling pathways.