Werner syndrome with torpid trophic ulcera cruris
Hürlimann, A.F.; Schnyder, U.W.
Der Hautarzt; Zeitschrift für Dermatologie Venerologie und verwandte Gebiete 42(11): 721-725
1991
ISSN/ISBN: 0017-8470 PMID: 1769837 Document Number: 383168
Werner's syndrome is a rare, autosomal recessive inherited disorder with a distinctive clinical picture. The characteristic physiognomy, shortness of stature with thin extremities, and large trophic ulcers are the key signs for the diagnosis. Premature greying of the hair and baldness, juvenile cataracts, a tendency to diabetes mellitus, hypogonadism, calcifications of the blood vessels, osteoporosis, metastatic calcifications of the soft tissue and an elevated incidence of neoplasms are further important features. We describe two patients with this disorder.