Clonal structural chromosomal rearrangements in lymphocytes of four patients with Werner's syndrome
Scappaticci, S.; Forabosco, A.; Borroni, G.; Orecchia, G.; Fraccaro, M.
Annales de Genetique 33(1): 5-8
1990
ISSN/ISBN: 0003-3995 PMID: 2369072 Document Number: 350289
Multiple numerical and structural chromosome abnormalities were found in cultured lymphocytes of four patients with Werner's syndrome. The proportion of metaphases with structural and/or numerical aberrations varied from 30 to 44% and several of them were clonal. These results confirm definitively that Werner's syndrome is a chromosome rearrangement syndrome and that these non-constitutional chromosome changes are not exclusive of cultured fibroblasts but present also in lymphocytes.