Behavior of Sa plasmid in tularemia pathogen cells
Pomerantsev, A.P.; Domaradskiĭ, I.V.; Shishkova, N.A.; Ershov, I.V.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 9: 17-21
1991
ISSN/ISBN: 0208-0613 PMID: 1745270 Document Number: 382578
The genome of Sa plasmid is shown to be a subject of genetical rearrangements in Francisella tularensis cells. The rearrangements either result in plasmid integration into the host cell genome or intramolecular amplification of cat-gene with the subsequent excision and recombination of the derivative plasmids. Stable inheritance of the plasmid is registered after integration while plasmid elimination occurs in case of extrachromosomal localisation.