Use of polymerase chain reaction of the HLA-DQ alpha system in forensic trace analysis

Schneider, P.M.; Prager-Eberle, M.; Rittner, C.

Archiv für Kriminologie 188(5-6): 167-174

1991


ISSN/ISBN: 0003-9225
PMID: 1799295
Document Number: 382440
The polymerase chain reaction (PCR) can be used for genetic typing of minute amounts of biological stains. This is achieved by in vitro amplification of a well-defined and genetically polymorphic human genomic DNA sequence. Using the HLA-DQ alpha system, a population study was carried out among 212 unrelated individuals of German origin. The usefulness of this system is discussed by presenting examples of its application in forensic casework, i.e. the analysis of mixed (male/female) body fluids as well as segregation studies on embryonic and paraffin-embedded tissue samples.

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