Transplantation of human prostatic carcinoma into nude mice in Matrigel
Pretlow, T.G.; Delmoro, C.M.; Dilley, G.G.; Spadafora, C.G.; Pretlow, T.P.
Cancer Research 51(14): 3814-3817
1991
ISSN/ISBN: 0008-5472 PMID: 2065335 Document Number: 381555
Previous successful transplantation of human primary prostatic carcinomas into nude mice has been described as "close to zero." When injected in Matrigel instead of culture medium, 25,000-fold fewer cells of the PC-3 human prostatic carcinoma cell line were required for the growth of tumors in nude mice during a 3-month period of observation; similar enhancement was observed with two other human prostatic carcinoma cell lines. Six of ten primary human prostatic carcinomas were transplanted successfully into nude mice when Matrigel was used as the vehicle.