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The antitumor effects of IFN- beta against human renal cell carcinoma in athymic nude mice

Shirahama, T.; Kayajima, T.; Ohi, Y.

In Vivo 3(5): 345-349

1989

ISSN/ISBN: 0258-851X
PMID: 2519876
Document Number: 337826
IFN-.beta. was more active than recombinant interferon-.alpha. (rIFN-.alpha.) and interferon-.gamma. (rIFN-.gamma.) in a human renal cell carcinoma transplanted in nude mice. In 3 out of 5 mice, the tumor completely disappeared and viable tumor cells were not observed at a daily dose of 5 .times. 105 U/mouse. Combination with anti-asialo GM1 antibody did not influence the tumor growth inhibition by IFN-.beta. Mononuclear cells around damaged cancer celsl were found not to be macrophages. Although the role of mononuclear cells remained unknown, the antitumor activity of IFN-.beta. seemed to depend on its direct cellular action. IFN-.beta. may be a useful agent in some renal cell carcinomas.

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