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Splenopentin--modulator of immunological and behavioral reactions in secondary immunodeficiency state induced by experimental alcoholism

Evseev, V.A.; Davydova, T.V.; Fomina, V.G.; Odariuk, I.; Repke, G.; Oeme, P.; Forner, K.

Biulleten' Eksperimental'noi Biologii i Meditsiny 111(6): 637-639

1991

ISSN/ISBN: 0365-9615
PMID: 1893194
Document Number: 381418
Effect of splenopentin on some patterns of immunity was studied in mice with chronic alcoholic intoxication. Splenopentin was administrated into animals once intraperitoneally (250 micrograms/kg). Administration of splenopentin was found to normalize several immunological patterns in animals with chronic alcoholic intoxication: the immune response to the thymus-dependent antigen sheep red blood cells and phagocytic activity of peritoneal macrophages. Also observations over C57B1/6 mice characterized by high level of alcoholic motivation showed that alcohol consumption in mice decreased after administration of splenopentin at a dose of 250 micrograms/kg during two weeks.

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