Immunological and cytochemical changes in groups at risk for acquired immunodeficiency syndrome and in symptomatic and asymptomatic carriers of antibodies to human immunodeficiency virus. a multivariate study
Gutiérrez Martín, M.; Romero Colás, M.S.; Callén Sevilla, L.; Lasierra Díaz, P.; Larrad Mur, L.
Medicina Clinica 89(13): 544-548
1987
ISSN/ISBN: 0025-7753 PMID: 3320599 Document Number: 292907
In 145 carriers of anti-HIV, 25 individuals from risk groups of AIDS without anti-HIV and 20 healthy individuals, the following measurements were performed: beta2-microglobulin, fibronectin, IgA, IgG, IgM, C3, C4, B factor of the complement, sensitivity skin tests, Th/Ts ratio, and lysozyme. IgG, IgM, lysozyme, Th/Ts ratio and fibronectin showed significant differences between the three groups. Beta2-microglobulin was only increased in anti-HIV carriers. When symptomatic and asymptomatic individuals were compared there were highly significant differences for beta2-microglobulin, skin tests, Th/Ts ratio and lysozyme. When anti-HIV positive symptomatic individuals, anti-HIV positive asymptomatic individuals, anti-HIV negative risk population and healthy individuals were compared using multivariate analysis, the more powerful discriminating variables were distributed in the following order: Th/Ts, beta2- microglobulin, IgG, fibronectin and C4. The variable that best discriminated between anti-HIV positive symptomatic individuals and anti-HIV positive asymptomatic individuals were skin tests; when instead of any symptom, only lymphadenopathy was considered, the best discriminating variable was Th/Ts ratio. The variables that best discriminated between anti-HIV negative risk groups and anti-HIV positive individuals were, by this order: IgG, beta2-microglobulin, C3, C4 and fibronectin. (Lysozyme was not included in the multivariate analysis).