Immunosuppressor activity of B-cells in patients with chronic lymphocytic leukemia. their possible role in the pathogenesis of the disease
Chernykh, E.R.; Tikhonova, M.A.; Ostanin, A.A.; Shevela, E.I.; Blazhievich, I.A.; Shubinskiĭ, G.Z.
Vestnik Akademii Meditsinskikh Nauk SSSR 12: 39-43
1991
ISSN/ISBN: 0002-3027 PMID: 1801472 Document Number: 381051
The data presented indicate that B cells from patients with chronic lymphocytic leukemia (CLL) may produce suppressive factors capable of inhibiting T and B cell proliferation and Ig secretion. Two factors with the molecular weight 65-75 KDa (SBF1) and 15-25 KDa (SBF2) have been characterized. SBFs are primarily produced by B cells with a low flow density. There is a reverse dependence between the capacity of leukemic B cells for spontaneous Ig secretion and their ability for the production of suppressive factors. The autocrine and paracrine pathways of B cell regulation in the pathogenesis of chronic lymphocytic leukemia are discussed.