The protective properties of monoamines and amino acids in an indomethacin-induced stomach lesion in rats
Sergeev, V.A.; Levkovets, V.S.
Farmakologiia i Toksikologiia 54(3): 37-39
1991
ISSN/ISBN: 0014-8318 PMID: 1915818 Document Number: 380959
Serotonin, histamine, tryptophan administered in low doses were shown to protect the rat gastric mucosa against indomethacin-induced hemorrhages. When administered in high doses, serotonin retained the protective properties, while histamine and histidine, on the contrary, increased the hemorrhagic lesion of the tissue. Tryptophan and histidine given in low doses promoted a decrease of the indomethacin elevated levels of serotonin and histamine in the gastric mucosa.