The experimental pharmacotherapy of the liver lesion induced by indomethacin
Skakun, N.P.; Klimniuk, E.V.
Farmakologiia i Toksikologiia 53(6): 52-54
1990
ISSN/ISBN: 0014-8318 PMID: 2081569 Document Number: 357170
In experiments on albino rats it was established that three administrations of indomethacin in a dose of 0.01 g/kg body weight induced a severe damage of the liver characterized by disturbances of hepatocytic membranes, bile-producing and protein-producing functions of the liver, an enhancement of lipid peroxidation, a decrease of reduced glutathione pool. Antioxidants (tocopherol acetate, essentiale, legalon, flacumin) limit manifestations of indomethacin, hepatotoxicity, as a result of which tha functional-biochemical disorders in the liver show up to a lesser degree. During the combined use of antioxidants in indomethacin-induced lesions of the liver their hepatoprotective activity increases.