Indomethacin- and Moduretic--induced hyperkalemia
Mor, R.; Pitlik, S.; Rosenfeld, J.B.
Israel Journal of Medical Sciences 19(6): 535-537
1983
ISSN/ISBN: 0021-2180 PMID: 6862860 Document Number: 201229
Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice. When administered alone, neither drug significantly changed the normal serum potassium levels. Laboratory findings suggest an alteration of the internal balance of potassium as the main mechanism of this particular drug-induced hyperkalemia.