The immunohistochemical study of lymphocyte subpopulations in benign and malignant epithelial tumors of the large intestine
Bandaletova, T.I.
Voprosy Onkologii 37(2): 193-196
1991
ISSN/ISBN: 0507-3758 PMID: 2014699 Document Number: 379727
Immunohistochemical methods using monoclonal antibodies were employed to semiquantitatively assess levels of B-lymphocytes and T-lymphocyte subpopulations (suppressors and helpers) in 12 moderately differentiated adenocarcinomas, five tubular adenomas, three villous tumors and in microscopically unaltered large bowel tissue. Helper/suppressor ratio was the most important characteristics of lymphocyte infiltrates. The parameter was significantly lower in adenocarcinoma as compared to tubular adenoma and microscopically unaltered mucosa.