Biological activity of kurilostatin--an unusual alkaloid from sea sponges

Popov, A.M.; Makar'eva, T.N.; Stonik, V.A.; Popov, A.M; Makar&apo; eva, T.N; Stonik, V.A

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Biological activity of kurilostatin--an unusual alkaloid from sea sponges

Popov, A.M.; Makar'eva, T.N.; Stonik, V.A.

Biofizika 36(5): 830-832

1991

ISSN/ISBN: 0006-3029

PMID: 1686831

Document Number: 379456

Biological activity of kurilostatin (KS), an unusual alkaloid from the sea sponge was studied. KS was shown to exert a strong cytostatic effect upon tumor cells and activated lymphocytes by mitogen. However it does not display any antitumoral activity in vivo. KS was found to induce release of free [Ca2+] from the above mentioned cells. This process is probably the basis of the cytostatic effect mechanism of KS.