Modulating effect of mast cells on the proliferation of cells from various lymphoid organs of rats
Gushchin, I.S.; Iamshchikova, O.A.; Prozorovskiĭ, N.S.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 6: 31-33
1991
ISSN/ISBN: 0031-2991 PMID: 1818282 Document Number: 379228
There are some reasons for suggesting that mast cells (MC) can modulate lymph cell (LC) activity. The blast-transformation test was used to study the effect of serum MC of Wistar and ACI rats on the proliferation of splenic, thymus and lymph node LC in vitro. Rat MC modulate lymphocyte proliferation. Depending on their concentrations, serum MC increased spontaneous and T-mitogen induced proliferation of splenic and lymph node cells. T-mitogen thymocyte proliferation was also increased. The promoting effect was maximal when the MC proliferative response was induced by suboptimal doses of mitogens. No genetical restriction was found for development of the MC promoting effect.