Accumulation of lipofuscin granules in acute myocardial infarct as a model of cell aging
Tatariunas, A.B.
Biulleten' Eksperimental'noi Biologii i Meditsiny 111(4): 443-446
1991
ISSN/ISBN: 0365-9615 PMID: 1893165 Document Number: 378671
Electron microscopic investigation of lipofuscin granules (LG) accumulation during one month in the myocardium of young rabbits in case of experimental acute infarction was performed. Accumulation of LG in cardiocytes of the ischemia-damaged myocardium area at the prenecrotic and necrotic stages was found. Analogous LG accumulation in cardiocytes in the perinecrotic area at the stage of infarction development was also observed. The fact of LG formation in fibroblast-like cells was also established. Cardiocytes and fibroblast-like cells contain a set of ultrastructurally varying LG. LG formation in functionally different cells of the ischemia-damaged myocardium is a further evidence of the active metabolic role of this organelle suggesting a common principle in LG genesis.