The origin of lipofuscin granules in a hybridoma cell culture
Tatariunas, A.B.
Biulleten' Eksperimental'noi Biologii i Meditsiny 107(3): 363-367
1989
ISSN/ISBN: 0365-9615 PMID: 2713481 Document Number: 328171
The ultrastructure of lipofuscin granules (LG) in hybridoma cells is described. Based on the electron microscopic evidence and literature data the possibility of generation of LG from cell endoplasmic reticulum (ER) is discussed. It is proposed that the production of LG is connected with disturbances in glycosylation of proteins and lipids on the ER membranes.
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