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Absence of radiation-induced adaptive response in lymphocytes of patients with Down's syndrome

Khandogina, E.K.; Mutovich, G.R.; Zvereva, S.V.; Zverev, D.O.; Neudakhin, E.V.; Arkhipov, B.A.; Akif'ev, A.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 112(9): 290-292

1991

ISSN/ISBN: 0365-9615
PMID: 1836143
Document Number: 377102
The adaptive syndrome and response (AR) in lymphocytes from 6 patients with Down syndrome (DS) were investigated. No AR was found to occur in all cases in DS cells pre-exposed to 3 rad of X-rays in S phase of cell cycle and then irradiated with 150 rad of gamma rays in G2 whereas the chromosome aberrations yield in cells from control donors was decreased twice under such conditions of the experiment.

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