Regulation of beta-adrenergic response in human lymphocytes: agonist induced subsensitivity
Lee, T.P.
Research Communications in Chemical Pathology and Pharmacology 22(2): 233-242
1978
ISSN/ISBN: 0034-5164 PMID: 216063 Document Number: 135408
The concentration of intracellular cAMP in lymphocytes is regulated by isoproterenol and PGE1. Preincubation of lymphocytes with isoproterenol leads to a loss of the response to beta-adrenergic agents but not to PGE1. Preincubation of lymphocytes with PGE1, however, affects the sensitivities both to isoproterenol and PGE1. A decrease of beta-adrenergic receptors was found in cells preincubated with isoproterenol but not with PGE1. Part of the abnormalities associated with PGE1-preincubated cells can be restored by treating the cells with theophylline.