Virus exposure diminishes beta-adrenergic response in human leukocytes
Lee, T.P.
Research Communications in Chemical Pathology and Pharmacology 30(3): 469-476
1980
ISSN/ISBN: 0034-5164 PMID: 6265987 Document Number: 161676
We used Ficoll-Hypaque isolated peripheral lymphocytes and PMNs to investigate the relationship between viral exposure and beta-adrenergic responses in target cells. Lymphocyte E-rosette formation with sheep red blood cells and PMN beta-glucuronidase release in response to opsonized zymosan particles are two cell activities regulated by beta-adrenergic agonists. After incubation with influenza or measles virus, the treated cells have decreased response to isoproterenol, a beta-adrenergic agonist. The in vitro viral exposure causes a decreased beta-adrenergic response in target cells.