Fluorophotometric evaluation of experimental blood-aqueous barrier disruption in dogs
Ward, D.A.; Ferguson, D.C.; Kaswan, R.L.; Green, K.; Bellhorn, R.W.
American Journal of Veterinary Research 52(9): 1433-1437
1991
ISSN/ISBN: 0002-9645 PMID: 1952328 Document Number: 376186
A protocol for performing slit-lamp fluorophotometry of the anterior chamber in dogs was established. The technique was then used to develop a model of blood-aqueous barrier disruption that can be used for comparative testing of ophthalmic anti-inflammatory drugs. It was determined that barrier disruption induced by a slow, controlled paracentesis of a small volume of aqueous humor may provide the most reliable model for drug testing. Additionally, fluorophotometry proved to be a sensitive and accurate means of detecting breakdown of the blood-aqueous barrier.