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Haematogenous osteomyelitis induced by strain SMU-0611 of Staphylococcus warneri in mice

Matsuoka, M.

Nihon Seikeigeka Gakkai Zasshi 65(11): 1112-1119

1991

ISSN/ISBN: 0021-5325
PMID: 1761911
Document Number: 374921
Strain SMU-0611 of Staphylococcus warneri isolated from clinical specimens (1.25 x 10(9) colony forming units) was intravenously administered into mice. Strain SMU-0611 caused remarkable inflammation characterized by roentgenographically recognizable changes in bone at 14 days after the injection. A number of organisms were detected in the bone marrow for as long as 35 days after the injection, suggesting specific lodgement of the strain in mouse bone marrow. Concerning the X-ray features of the mice, multiple foci of osteolytic changes were shown in the metaphysis of the femur and the tibia obtained 14 days after the injection. However, these changes did not aggravate at all for 56 days after the injection.

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