Antimalarial activity of deoxoqinghaosu
Ye, B.; Wu, Y.L.; Li, G.F.; Jiao, X.Q.
Yao Xue Xue Bao 26(3): 228-230
1991
ISSN/ISBN: 0513-4870 PMID: 1957665 Document Number: 374164
Compound 3 (deoxoqinghaosu) and compared 4 (deoxocarbaqinghaosu) were synthesized from arteannuic acid (2). Primary exploration of their antimalarial effect against K173 strains of Plasmodium berghei shows that compound 3 is somewhat more effective than the natural compound .sbd. qinghaosu. However, the carba-analgoue compound 4 is almost ineffective. The enhanced activity of compound 3 is supposedly ascribed to its higher lipophilicity and, hence, higher affinity for plasmodial membranes. Further studies are in progress.